Exploratory Research

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【Exploratory Research】Methods of bioassay
Name of assay Target diseases of assay
Stimulatory effect on hepatocyte growth Digestive system
Inhibitory effect on the enzyme activity of amylase Digestive system
Inhibitory effect on PAI-1 production Cardiovascular system
Inhibitory effect on the enzyme activity of streptococcal NADase Infective disease
Agonist activity against AhR Endcrine & Metabolic systems
Inhibitory effect on the enzyme activity of serine-carboxyl protease Brain, Nervous system
Inhibitory effect on the enzyme activity of prolyl tripeptidyl peptidase from Porphyromonas gingivalis Infective disease
Effect on the cellular snRNP level Others
Inhibitory effect on cholesterol synthesis Endcrine & Metabolic systems
Inhibitory effect on NFAT promoter activity Immune system, Allergy
Inhibitory effect on NO production Brain, Nervous system
Cytotoxicity against PANC-1 cell Cancer
Stimulatory effect on BDNF gene expression Brain, Nervous system
Cytotoxicity against Jurkat cell Cancer
Inhibitory effect on MTH1 enzyme activity Cancer
Inhibitory effect on lipid droplet accumulation Endcrine & Metabolic systems
Inhibitory effect on NS2B-NS3 enzyme activity Infective disease
Inhibitory effect on hydrogen sulfide-producing enzyme activity Infective disease
Inhibitory effect on Toxoplasma gondii proliferation Infective disease
Inhibitory effect on the replication of Borna disease virus Infective disease
Inhibitory effect on the promoter activity of Piwil1 (Miwi) gene Others
Inhibitory effect on the promoter acitivity of retrotransposon Others
Inhibitory effect on the reverse transcriptase activity of hepatitis B virus DNA polymerase Infective disease
Inhibitory effect on the enzyme activity of SuperScript II reverse transcriptase Others
Stimulatory effect on neurite outgrowth Brain, Nervous system
Stimulatory and Inhibitory Effects on hydrolysis activity of hyaluronidase Others
Antitrypanosomal activity Infective disease
Inhibitory effect on Btg2 gene expression Brain, Nervous system
Stimulatory effect on secondary metabolite production by Aspergillus fumigatus Others
Inhibitory effect on the enzyme activity of endoplasmic reticulum glucosidase Infective disease
Inhibitory effect on the enzyme activity of galactosidase Infective disease
Inhibitory effect on the enzyme activity of allosidase Infective disease
Inhibitory effect on morphological changes of breast cancer cells Cancer
Stimulatory effect on the transcriptional regulator activity of YAP1 Cancer
Inhibitory effect on the enzyme activity of HDAC Cancer
Cytotoxicity against HL60 cells Cancer
Activation of NLRP3 inflammasome Immune system, Allergy
 

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Metabolism information on chemical compounds included in crude drugs

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Division of Pharmacognosy,
Department of Medicinal Resources,
Institute of Natural Medicine,
University of Toyama
2630 Sugitani, Toyama 930-0194 Japan
TEL: +81-76-434-7601
FAX: +81-76-434-5064