Ganoderiol F
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| Compound | Ganoderiol F |
| Animal species | human and rat intestinal microflorarat |
| Metabolism parameters |
Intravenous administration Oral administration Oral administration |
| Metabolites |
Ganoderiol F
Ganodermatriol |
| Crude drug | Ganoderma |
| References | 1) Zhang Q., Zuo F. Nakamura N., Ma C. M., and Hattori M.: Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. J. Nat. Med., 63, 304-310 (2009). |
| Remarks | Fresh feces (5 g each) from rats were suspended in 100 ml of GAM broth, and used for bacterial transformation of ganoderiol F (GF) in vitro; GF (2 mg) dissolved in 40 ml of MeOH and the above bacterial mixture (500 μl) were added to GAM broth (5 ml) and incubated at 37°C for 7 d under anaerobic conditions. Portions (200 μl) were removed at intervals and mixed with MeOH (400 μl). The mixture was centrifuged at 604 ×g for 15 min, and the upper layer was passed through a liquid chromatography disc followed by centrifugation at 6700 ×g for 5 min. Portions of supernatants were analyzed by HPLC/MS/MS. |
