Ginsenoside Re
Ginsenoside Rg1 （追加）
Ginsenoside Rg1 （追加）
|
| Compound | Ginsenoside Re Ginsenoside Rg1 （追加） |
| Animal species | mouse |
| Metabolism parameters |
Oral administration Oral administration Oral administration Oral administration |
| Metabolites |
20(S)-Ginsenoside Re
|
| Crude drug | Ginseng |
| References | 1) Kyung-Mi Joo, Ji-Hae Lee, Hee-Young Jeon, Chan-Woong Park, Deok-Ki Hong, Hye-Jin Jeong, Sang Jun Lee, Seok-Yong Lee, Kyung-Min Lim, Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method. Journal of Pharmaceutical and Biomedical Analysis, 51, 278–283 (2010). 2) Xiaoyu Li, Jianguo Sun, Guangji Wang, Haiping Hao, Yan Liang, Yuanting Zheng, Bei Yan and Longsheng Sheng, Simultaneous determination of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional Chinese medicine. Biomedical Chromatography, 21: 735–746 (2007). DOI: 10.1002/bmc.813 3) Liang Feng, Ling Wang, Changjiang Hu, and Xuehua Jiang, Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats. Arch Pharm Res, 33: 1975-1984 (2010). DOI 10.1007/s12272-010-1213-2 4) Liu Yang, Shun-jun Xu, Zhi-feng Wu, Yi-Ming Liu and Xing Zeng, Determination of ginsenoside-Rg1 in human plasma and its application to pharmacokinetic studies following intravenous administration of 'Shenmai' Injection. Phytother. Res. 23, 65–71 (2009). DOI: 10.1002/ptr.2558 5) Han Min, Fu Shao, Fang Xiao-ling, Comparison between the characteristics of absorption and pharmacokinetic behavior of ginsenoside Rg1 and ginsenoside Rb1 of Panax notoginseng saponins. Acta Pharmaceutica Sinica（薬学学報）, 42, 849-853 (2007). 6) Xiaoyu Li, Jianguo Sun, Guangji Wang, Haiping Hao, Yan Liang, Yuanting Zheng, Bei Yan and Longsheng Sheng, Simultaneous determination of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional Chinese medicine. Biomedical Chromatography, 21: 735–746 (2007). DOI: 10.1002/bmc.813 7) Gui-feng Deng, Ding-li Wang, Ming-xin Meng, Fan Hu, Tong-wei Yao, Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877: 2113–2122 (2009). |
| Remarks | Following the intravenous and oral administration of pure Re（major ginsenoside in ginseng berry）or a ginseng berry extract in mouse with doses of 10 and 50 mg/kg monitored by ultra performance liquid chromatography mass spectrometry (UPLC/MS), ginsenoside Re was rapidly cleared from the body with a short half-life (0.2±0.03 h for male and 0.5±0.08 h for female mice after i.v., and the oral absorption was generally poor (F% 0.19–0.28). Notably, GB extract showed a superior oral absorption of ginsenoside Re (F% 0.33–0.75) at equivalent ginsenoside Re dose to pure ginsenoside Re. [ Joo et al., Journal of Pharmaceutical and Biomedical Analysis, 51, 278–283 (2010)] Pharmacokinetic parameters of ginsenoside Re and GB extract after oral (10, 50 mg/kg) administration to ICR mice. Data are expressed as mean±SD (N= 7). Difference from corresponding ginsenoside Re group, *P < 0.1, **P < 0.05 [ Joo et al., Journal of Pharmaceutical and Biomedical Analysis, 51, 278–283 (2010)] |
