Oral administration
Dose | 40 mg/kg |
K | |
T1/2 | 9.53 ± 3.2 h ^a |
Tmax | |
V | |
CL | |
Cmax | |
AUC | 253.2 ± 124.5 ng∙h∙ml^-1 ^b |
Range of AUC | 0-limit |
MRT | 10.9 ± 2.4 h ^a |
MAT | 1.71 ± 0.8 h |
Others | |
Comment | a p< 0.05, b p< 0.01 compared with conventional rats; Data are expressed as means±S.D. (n = 4). Ber, berberine; M1, berberrubine; M2, thalifendine: M3, demethyleneberberine; M4, jatrorrhizine. |
Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters