1-(2', 6'-Dihydroxyl-3', 4'-dimethoxyphenyl)-3-(4''-hydroxyphenyl) propan-1-one
|参考文献||1) Li Y., Meselhy M. R., Wang L., Ma C., Nakamura N., and Hattori M.: Biotransformation of a C-glycosylflavone, abrusin 2"-O-β-D-apioside, by human intestinal bacteria. Chem. Pharm. Bull., 48, 1239-1241 (2000).
2) Ma C. M., Nakamura N., and Hattori M.: Saponins and C-glucosyl flavones from the seeds of Abrus precatorius. Chem. Pharm. Bull. 46, 982-987 (1998).
|論文備考||※Preparation of an intestinal bacterial mixture
Fresh feces obtained from a healthy subject were thoroughly suspended in 100-fold of 50 mM K-phosphate buffer (pH 7.3) to give a human fecal suspension, which was use in this experiment. [Li et al., Chem. Pharm. Bull., 48, 1239-1241 (2000)]
※Time course of the transformation of precatorin II
Precatorin II (3, 10 mmol in 200 ml of DMSO) was added to a human fecal suspension (5%, 3.8 ml) and incubated at 37°C in an anaerobic incubator. Samples were picked up at intervals and treated as mentioned above. Metabolites were quantitatively determined by HPLC. [Li et al., Chem. Pharm. Bull., 48, 1239-1241 (2000)]