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Ginsenoside Ra3
Ginsenoside Ra3

化合物名 Ginsenoside Ra3 
動物種 ラット 
代謝パラメータ  
代謝物 (20S)-Ginsenoside Ra3
関連生薬 人参 
参考文献 1) Houfu Liu, Junling Yang, Feifei Du, Xiumei Gao, Xutao Ma, Yuhong Huang, Fang Xu, Wei Niu, Fengqing Wang, Yu Mao, Yan Sun, Tong Lu, Changxiao Liu, Boli Zhang, and Chuan Li, Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metabolism and Disposition, 37: 2290–2298 (2009). 
論文備考 Ginsenosides were administered to rats, either in the form of Sanqi extract or as pure chemicals. Systemic exposure to ginsenosides Ra3, Rb1, and Rd after oral administration of the extract was significantly greater than that to the other compounds. Considerable colonic deglycosylation of the ginsenosides occurred, but the plasma levels of deglycosylated metabolites were low in rats. Poor membrane permeability and active biliary excretion are the two primary factors limiting systemic exposure to most ginsenosides and their deglycosylated metabolites. [Li et al., Drug Metabolism and Disposition, 37: 2290–2298 (2009)]