Swertiamarin
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| 化合物名 | Swertiamarin |
| 動物種 | 腸内細菌 |
| 代謝パラメータ | |
| 代謝物 |
Swertiamarin
02 2-oxo-4-(1-oxobut-3-en-2-yl)-5,6-dihydro-2H-pyran-3-carbaldehyde 2-oxo-4-(1-oxobut-3-en-2-yl)-5,6-dihydro-2H-pyran-3-carbaldehyde 8-hydroxy-1-oxo-3,4,7,8-tetrahydro-1H-isochromene-5-carbaldehyde Erythrocentaurin 5-(Hydroxymethyl)isochroman-1-one Gentianine |
| 関連生薬 | センブリ , 竜胆 |
| 参考文献 | 1) El-Sedawy A. I., Shu Y. Z., Hattori M., Kobashi K. and Namba T.: Metabolism of swertiamarin from Swertia japonica by human intestinal bacteria. Planta Med., 55, 147-150 (1989). |
| 論文備考 | ・Metabolism of swertiamarin by a bacterial mixture from human feces Fresh feces obtained from a healthy subject were immediately transrerred into a vinyl bag filled with oxygen-free CO2. The bag was then pressed by hand to uniformly mix the content. A portion (5 g) was suspended in 0.1 M phosphate buffer (100 ml, pH 7.4) and filtered through gauze The filtrate was divided into three portions. Swertiamarin (200 mg) was added to each and the samples were incubated for 14, 24, and 48 h at 37°C in an anaerobic jar, in which air had been replaced by oxygen-free CO2 in the presence of steel wool (steel wool method). The mixture was extracted with EtOAc and the metabolites were analyzed by TLC-densitometry. |
