Secoisolariciresinol
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| 化合物名 | Secoisolariciresinol |
| 動物種 | ヒト腸内細菌単離株 END-2 及び ARC-1 |
| 代謝パラメータ | |
| 代謝物 |
(-)-Secoisolariciresinol
(-)-Enterodiol (+)-Secoisolariciresinol (+)-Enterolactone |
| 関連生薬 | |
| 参考文献 | 1) Jin J. S. and Hattori M.: Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism. Biol. Pharm. Bull., 33, 1443-1447 (2010). |
| 論文備考 | ・Culture of secoisolariciresinol with two human intestinal bacterial strains END-2 and ARC-1 Each substrate (0.1 mM) of (+)- or (-)-secoisolariciresinol was anaerobically incubated with a mixture of strains END-2 and ARC-1 for 120 h, and then a portion (100 μl) was extracted with ethyl acetate, which was then evaporated in vacuo. The residue was dissolved in 0.3 ml of MeOH, filtered through a 0.45-μm membrane and a portion (10 μl) was analyzed by LC/MS. Substrate conversion was also confirmed by TLC. [Jin et al., Biol. Pharm. Bull., 33, 1443-1447 (2010)] |
