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Epicatechine
Epicatechine

化合物名 Epicatechine 
動物種 ヒト腸内細菌 Eubacterium sp. strain SDG-2 
代謝パラメータ  
代謝物 (+)-(2S 3S)-Epicatehin
(R)-2-(3-(3,4-dihydroxyphenyl)-2-hydroxypropyl)benzene-1,3,5-triol
(-)-(2R, 3S)-Epicatechin
(S)-2-(3-(3,4-dihydroxyphenyl)-2-hydroxypropyl)benzene-1,3,5-triol
(S)-2-(2-hydroxy-3-(3-hydroxyphenyl)propyl)benzene-1,3,5-triol
(-)-Epigallocatechin (2R, 3R)
(S)-5-(2-hydroxy-3-(2,4,6-trihydroxyphenyl)propyl)benzene-1,2,3-triol
(S)-2-(3-(3,5-dihydroxyphenyl)-2-hydroxypropyl)benzene-1,3,5-triol
関連生薬 阿仙薬 
参考文献 1) Wang L., Meselhy M. R., Li Y., Nakamura N., Min B., Qin G. and Hattori M.: The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium. Chem. Pharm. Bull., 49, 1640-1643 (2001). 
論文備考 ・Incubation of (+)-epicatechin with Eubacterium sp. strain SDG-2
(+)-Epicatechin (1a) (10 mg in 1 ml MeOH) was anaerobically incubated with a bacterial suspension (20 ml) for 36 h. The reaction mixture was then treated as usual to give 2a (4 mg). [Wang et al., Chem. Pharm. Bull., 49, 1640-1643 (2001)]
・Incubation of (-)-epicatechin with E. sp. strain SDG-2
(-)-Epicatechin (1b) (30 mg in 1 ml MeOH) was anaerobically incubated with a bacterial suspension for 36 h. The reaction mixture was then treated as usual to give 2b (10 mg) and 3b (8 mg), respectively. [Wang et al., Chem. Pharm. Bull., 49, 1640-1643 (2001)]
 
 

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