Cinobufagin
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| 化合物名 | Cinobufagin |
| 動物種 | 微生物、ラット |
| 代謝パラメータ |
Intragastric administration |
| 代謝物 |
Cinobufagin
3-Acetyl cinobufagin |
| 関連生薬 | 蟾酥 |
| 参考文献 | 1) Jian Zhang, Yang Sun, Ji-Hua Liu, Bo-Yang Yu, and Qiang Xu, A Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure–activityrelationship (SAR). Bioorganic & Medicinal Chemistry Letters 17, 6062–6065 (2007). 2) Wen Xu, Heng Luo, Yaping Zhang, Lei Shan, Haiyun Li, Ming Yang, Runhui Liu, Weidong Zhang, Simultaneous determination of five main active bufadienolides of Chan Su in rat plasma by liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 859, 157–163 (2007). |
| 論文備考 | 【代謝実験】① Chan Suに含まれるbufadienolide [Zhang et al., Bioorg. Med. Chem. Lett. 17, 6062–6065 (2007)]. ② Chan Su胃内投与後の血清中のbufadienolide [Xu et al., J.Chromato. B, 859, 157–163 (2007)]. Pharmakokinetic parameters of bufadienolides in serum after intragastric administration of Chan Su extract to rats at a dose of 100 mg /kg (n=6) Mean±SD |
