メニュー  → 生薬成分の代謝  → 
Ginsenoside Rh1
Ginsenoside Rh1

化合物名 Ginsenoside Rh1 
動物種 mouse 
代謝パラメータ Intravenous administration
Intragastric administration
代謝物 20(S)-Ginsenoside Rh1
関連生薬 人参 
参考文献 1) Li Lai, Haiping Hao, Yitong Liu, Chaonan Zheng, QiongWang, Guangji Wang, Xijin Chen, Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro. Planta Med., 75: 797–802 (2009). 
論文備考 The absolute bioavailability of 20(S)-ginsenoside Rh1 in
rats was only 1.01%. After intragastrical administration of ginsenoside Rh1, two mono-oxygenated metabolites were detected from the urine, bile, liver tissue, and intestinal tract content, while the de-glucosylated product, 20(S)-protopanaxatriol, was only found in the contents of the intestinal tract.
An in vitro incubation study confirmed that the CYP450-catalyzed mono-oxygenation, the intestinal bacteria mediated de-glucosylation, and the gastric acid mediated hydration reaction were the main metabolic pathways of 20(S)-ginsenoside Rh1. [Lai et al., Planta Med., 75: 797–802 (2009)]

The main pharmacokinetic parameters of Rh1 after i. v. (5 mg/kg) and i. g. (50mg/kg) administrations (mean ± S.D., n = 4).
CL/F: apparent oral total body clearance (where F represents bioavailability); CL: total clearance; Cmax: the maximum plasma concentration; F: bioavailability; MRT: mean retention time; T1/2α: the absorption half-life time; T1/2β: the apparent elimination half-life time; Tmax: the time to reach Cmax; Vd: the apparent volume of distribution. [Lai et al., Planta Med., 75: 797–802 (2009)] 
 

TOPICS

遺伝子解析情報

活性試験情報

生薬成分の代謝情報

伝統医薬データベース


富山大学和漢医薬学総合研究所
研究開発部門
資源開発分野
資源科学領域
〒930-0194
富山県富山市杉谷 2630
TEL: 076-434-7601
FAX: 076-434-5064