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Piperine
Piperine

化合物名 Piperine 
動物種 ラット 
代謝パラメータ  
代謝物 Piperine
関連生薬  
参考文献 1) Xinan Wu, Xingguo Chen and Zhide Hu: High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma. Talanta 59: 115-121 (2003).

2) Böhmdorfer M, Maier-Salamon A, Taferner B, Reznicek G, Thalhammer T, Hering S, Hüfner A, Schühly W and Jäger W: In vitro metabolism and disposition of honokiol in rat and human livers. Journal of Pharmaceutical Sciences, 100: 3506–3516 (2011).

3) Qin Yu, Jin Xiang, WenFu Tang, MaoZhi Liang, YongPing Qin and Feng Nan: Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 877: 2025–2031 (2009). 
論文備考 Separate sets of animals (150 - 160 g) were orally administered the three spice principles at dosages of 30 mg (capsaicin), 170 mg (piperine) and 500 mg (curcumin) / kg body weight. The tissue concentrations of administered spice compounds were determined by HPLC. A maximum of 10.8 per cent of administered piperine was seen in tissues at 6 h. Absorption of the administered piperine was about 96 per cent. Piperine was not detectable in urine. [Suresh et al., Indian J Med Res 131, 682-691 (2010)] 
 

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