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お知らせ
| データのコピー防止をしました | 2021/03/16 |
| 全てのページで右クリック、選択、コピーが出来ないようにしました。 加えて、生薬の画像に透かしを入れました。 |
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| データベースの引用方法について | 2021/02/03 |
| 学術論文、学術集会等で本データベースを利用した成果を発表する場合には、必ずその旨を明記して下さい。 和文の例: 本研究は、富山大学和漢医薬学総合研究所の伝統医薬データベース (https://dentomed.toyama-wakan.net/) の情報を利用して行われた。 英文の例: This research was performed by utilizing the Traditional Medical & Pharmaceutical Database, Institute of Natural Medicine, University of Toyama (https://dentomed.toyama-wakan.net/index_en). |
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| 一部ページの表示を変えました | 2021/02/03 |
| 試験薬物ページ、活性試験情報ページ、サインイン時の画面表示を変えました。 | |
| 和漢薬Wikiデータベースよりデータを移行しました | 2020/11/26 |
| 和漢薬Wikiデータベースより生薬と漢方方剤のデータを移行しました。 | |
| Link | |
| 学名表記を一部修正しました | 2020/10/23 |
| 生薬学術情報の基原欄の学名表記を以下の方針に従い修正しました。 『生薬の植物学名は，「The International Plant Names Index (IPNI), http://www.ipni.org/」を指針に記載する．ただし，学名の命名者名の姓はフルスペルで記載し，基礎異名の命名者名は省略する．』（第十八改正日本薬局方原案作成要領より引用） |
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| 日本語ページの一部にアクセス制限をかけました | 2020/02/28 |
| 日本語ページの一部にアクセス制限をかけ、登録ユーザだけが閲覧できるように変更しました。 | |
| 探索研究論文情報の追加 | 2019/05/15 |
| 探索研究に関する論文の情報を追加しました。探索研究の詳しい説明はリンク先をご覧下さい。 | |
| Link | |
| 伝統医薬データベース英語版の公開 | 2012/12/26 |
| 2012年12月26日から伝統医薬データベースの英語版 Traditional Medical & Pharmaceutical Database を公開します。 これに伴い、日本語版も機能を追加しました。 |
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探索研究論文
| 2022 (探索研究) | 2022/06/10 |
| - Ngwe Tun M. M., Toume K., Luvai E., Nwe K. M., Mizukami S., Hirayama K., Komatsu K., Morita K.: The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro. J. Nat. Med., 76(2):402-409 (2022). doi: 10.1007/s11418-021-01596-w - Ngwe Tun M. M., Luvai E., Nwe K. M., Toume K., Mizukami S., Hirayama K., Komatsu K., Morita K.: Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro. Arch. Virol., 167(7):1547-1557 (2022). doi: 10.1007/s00705-022-05483-x - Ikeda Y., Funamoto M., Kishi S., Imanishi M., Aihara K.-I., Kashiwada Y., Tsuchiya K.: The novel preventive effect of a Japanese ethical Kampo extract formulation TJ-90 (Seihaito) against cisplatin-induced nephrotoxicity. Phytomedicine, 103:154213 (2022). doi: 10.1016/j.phymed.2022.154213 |
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| 2021 (探索研究) | 2022/06/10 |
| - Rahman M. A., Ueda K., Honda T.: A Traditional Chinese medicine, maoto, suppresses hepatitis B virus production. Front. Cell. Infect. Microbiol., 10:581345 (2021). doi: 10.3389/fcimb.2020.581345 | |
| 2020 (探索研究) | 2022/06/10 |
| - Terabayashi T., Tokumaru A., Ishizaki T., Hanada K.: Analysis of chromosomal DNA fragmentation in apoptosis by pulsed-field gel electrophoresis. Methods Mol. Biol., 2119:89-99 (2020). doi: 10.1007/978-1-0716-0323-9_8 - Teklemichael A. A., Mizukami S., Toume K., Mosaddeque F., Kamel M. G., Kaneko O., Komatsu K., Karbwang J., Huy N. T., Hirayama K.: Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds. Malar. J., 19(1):204 (2020). doi: 10.1186/s12936-020-03273-x - Miura K., Onodera C., Takagi M., Koyama R., Hirano T., Nishio T., Hakamata W.: Screening, synthesis, and evaluation of novel isoflavone derivatives as inhibitors of human golgi β-galactosidase. Chem. Pharm. Bull., 68(8):753-761 (2020). doi: 10.1248/cpb.c20-00194 |
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| 2019 (探索研究) | 2022/06/10 |
| - Fukuchi M., Okuno Y., Nakayama H., Nakano A., Mori H., Mitazaki S., Nakano Y., Toume K., Jo M., Takasaki I., Watanabe K., Shibahara N., Komatsu K., Tabuchi A., Tsuda M.: Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice. Sci. Rep., 9(1):11833 (2019). doi: 10.1038/s41598-019-48361-4 | |
| 2018 (探索研究) | 2022/06/10 |
| - Fujii E., Inada Y., Kakoki M., Nishimura N., Endo S., Fujiwara S., Wada N., Kawano Y., Okuno Y., Sugimoto T., Hata H.: Bufalin induces DNA damage response under hypoxic condition in myeloma cells. Oncol. Lett., 15(5):6443-6449 (2018). doi: 10.3892/ol.2018.8091 - Terabayashi T., Hanada K., Motani K., Kosako H., Yamaoka M., Kimura T., Ishizaki T.: Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment. Genes Cells, 23(6):466-479 (2018). doi: 10.1111/gtc.12584 - Nishikawa Y., Nakayama R., Obika S., Ohsaki E., Ueda K., Honda T.: Inhibition of LINE-1 retrotransposition by capsaicin. Int. J. Mol. Sci., 19(10):3243 (2018). doi: 10.3390/ijms19103243 - Watanabe K.: Drug-repositioning approach for the discovery of anti-influenza virus activity of Japanese herbal (Kampo) medicines in vitro: Potent high activity of Daio-Kanzo-To. Evid. Based Complement. Alternat. Med., 2018:6058181 (2018). doi: 10.1155/2018/6058181 |
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| 2017 (探索研究) | 2022/06/10 |
| - Hishiki T., Kato F., Miura T., Tajima S., Toume K., Umezaki M., Takasaki T.: Hirsutine, an indole alkaloid of Uncaria rhynchophylla, inhibits late step in Dengue virus lifecycle. Front. Microbiol., 8:1674 (2017). doi: 10.3389/fmicb.2017.01674 | |
| 2016 (探索研究) | 2022/06/10 |
| - Chiba M., Ariga H., Maita H.: A splicing reporter tuned to non-AG acceptor sites reveals that luteolin enhances the recognition of non-canonical acceptor sites. Chem. Biol. Drug Des., 87(2):275-282 (2016). doi: 10.1111/cbdd.12656 | |
| 2015 (探索研究) | 2022/06/10 |
| - Wada N., Kawano Y., Fujiwara S., Kikukawa Y., Okuno Y., Tasaki M., Ueda M., Ando Y., Yoshinaga K., Ri M., Iida S., Nakashima T., Shiotsu Y., Mitsuya H., Hata H.: Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells. Int. J. Oncol., 46(3):963-972 (2015). doi: 10.3892/ijo.2014.2804 | |
| 2014 (探索研究) | 2022/06/10 |
| 2013 (探索研究) | 2022/06/10 |
| 2012 (探索研究) | 2022/06/10 |
| - Ishimoto T., Mano H., Ozawa T., Mori H.: Measuring CREB activation using bioluminescent probes that detect KID-KIX interaction in living cells. Bioconjug. Chem., 23(5):923-932 (2012). doi: 10.1021/bc200491j | |
| 2011 (探索研究) | 2022/06/10 |
| 2010 (探索研究) | 2022/06/10 |
知的クラスター論文
| 2013 (知的クラスター) | 2013/12/05 |
| - Piao J. L., Cui Z. G., Furusawa Y, Ahmed K, Rehman M. U., Tabuchi Y., Kadowaki M., Kondo T.: The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells. Chem Biol Interact, 205: 119-127, 2013. [ PMID: 23811387] - Teshigawara K., Kuboyama T., Shigyo M., Nagata A., Sugimoto K., Matsuya Y., Tohda C.: A novel compound, Denosomin ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin. Br J Pharmacol, 168: 903-919，2013. [PMID: 22978525] - He J. Y., Zhu S., Komatsu K., Goda Y., Cai S. Q.: Genetic polymorphism of medicinally-used Codonopsis species in an internal transcribed spacer sequence of nuclear ribosomal DNA and its application to authenticate Codonopsis Radix. J. Nat. Med., 2013. 10.1007/s11418-013-0780-1 [PMID: 23765107] - He J. Y., Zhu S., Goda Y., Cai S. Q., Komatsu K.: Quality Evaluation of Medicinally-used Codonopsis Species and Codonopsis Radix Based on the Contents of Pyrrolidine Alkaloids, Phenylpropanoids and Polyacetylenes. J. Nat. Med., 2013. 10.1007/s11418-013-0801-0 [PMID: 24203345] |
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| 2012 (知的クラスター) | 2013/12/05 |
| - Wang X., Kageyama-Yahara N., Hayashi S., Yamamoto T., Kadowaki M.: Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice. Evid Based Complement Alternat Med, 2012: 862743, 2012. [PMID: 22719791] - Ahmed K., Furusawa Y., Tabuchi Y., Emam HF., Piao JL., Hassan MA., Yamamoto T., Kondo T., Kadowaki M.: Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response. Int J Hyperther, 28: 1-8, 2012. [PMID: 22235779] - Tohda C., Urano T., Umezaki M., Nemere I., Kuboyama T.: Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Sci Rep, 2: 535, 2012. [PMID: 22837815] - Tohda C., Nagata A.: Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury. Evid Based Complement Alternat Med, 2012: 731208, 2012. [PMID: 22956977] - Wang X.H., Zhu H., Konno K., Tohda C., Kazuma K., Kuboyama T., Miyanaga S.: Screening of fractions from some Chinese herbs for spinal cord injury. Chinese Journal of Experimental Traditional Medical Formulae, 18: 246-248, 2012. |
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| 2011 (知的クラスター) | 2013/12/05 |
| - Kageyama-Yahara N., Wang X., Katagiri T., Wang P., Yamamoto T., Tominaga M., Kadowaki M.: Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells. Biochem Biophys Res Commun, 416: 283-288, 2011. [PMID: 22100653] - Tohda C., Nakada R., Urano T., Okonogi A., Kuboyama T.: Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer’s disease, 5XFAD. Int J Neurosci, 121: 641-648, 2011. [PMID: 21770858] - Oka H., Goto H., Koizumi K., Nakamura S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki I., Shimada Y.: Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evid Based Complement Alternat Med, 2011: 348686, 2011. [PMID: 21423692] - Kimura M., Shibahara N., Hikiami H., Yoshida T., Jo M., Kaneko M., Nogami T., Fujimoto M., Goto H., Shimada Y.: Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats. Evid Based Complement Alternat Med., 2011: 592791, 2011. [PMID: 21660308] - Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.: Cinnamaldehide and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia. J Trad Med, 28: 149-157, 2011. - Bai Y. J., Tohda C., Zhu S., Hattori M., Komatsu K.: Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. J. Nat. Med., 65: 417-423, 2011. [PMID: 21301979] - Kitani Y., Zhu S., Batkhuu J., Sanchir C., Komatsu K.: Genetic diversity of Ephedra plants in Mongolia inferred from nrDNA ITS sequence. Biol. Pharm. Bull., 34: 717-726, 2011. [PMID: 21532163] - Zhu S., Oya M., Bai Y. J., Tanaka K., Komatsu K., Maruyama T., Goda Y., Kawasaki T., Fujita M., Shibata T.: Genetic and chemical diversity of Eleutherococcus senticosus and molecular identification of Siberian ginseng by PCR-RFLP analysis based on chloroplast trnK intron sequence. Food Chemistry, 129: 1844-1850, 2011. [Abstract] |
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