Oral administration
Dose | 40 mg/kg |
K | |
T1/2 | 8.57 ± 3.9 h |
Tmax | |
V | |
CL | |
Cmax | |
AUC | 655.9 ± 204.3 ng∙h∙ml^-1 ^a |
Range of AUC | 0-limit |
MRT | 15.20 ± 4.8 h ^a |
MAT | 6.76 ± 2.4 h |
Others | |
Comment | a p< 0.05, b p< 0.01 compared with conventional rats; Data are expressed as means±S.D. (n = 4). Ber, berberine; M1, berberrubine; M2, thalifendine: M3, demethyleneberberine; M4, jatrorrhizine. |
Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters