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Pinoresinol diglucoside
Pinoresinol diglucoside

Compound Pinoresinol diglucoside 
Animal species human intestinal bacteria 
Metabolism parameters  
Metabolites Pinoresinol diglucoside
(+)-Pinoresinol
(+)-Lariciresinol
3'-Demethyl-(+)-Lariciresinol
(-)-Secoisolariciresinol
(-)-3-(3",4"-Dihydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl) butane-1,4-diol
2-(3',4'-Dihydroxybenzyl)-3-(3",4"-dihydroxybenzyl)butane-1,4-diol
3-(3''-Hydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butane-1,4-diol
2-(3',4'-Dihydroxybenzyl)-3-(3"-hydroxybenzyl)butane-1,4-diol
(-)-Enterodiol
(-)-(2R,3R)-3-(3",4"-Dihydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butyrolactone
(-)-(2R,3R)-2-(3',4'-Dihydroxybenzyl)-3-(3",4"-dihydroxybenzyl) butyrolactone
(-)-(2R,3R)-3-(3"-Hydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butyrolactone
2-(3',4'-Dihydroxybenzyl)-3-(3"-hydroxybenzyl)butyrolactone
2-(3'-Hydroxybenzyl)-3-(3",4"-dihydroxybenzyl) butyrolactone
(-)-(2R,3R)-Enterolactone
Crude drug Eucommia Bark 
References 1) Xie L., Akao T., Hamasaki K., Deyama T. and Hattori M.: Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of Enterococcus faecalis strain PDG-1responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol. Chem. Pharm. Bull., 51, 508-515 (2003).
2) Gao J. J. and Hattori M.: Metabolic activation of lignans to estrogenic and anti-eatrogenic substances by human intestinal bacteria. J. Trad. Med., 22, 213-221 (2005). 
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