Icariin
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| Compound | Icariin |
| Animal species | rat, human, dog |
| Metabolism parameters |
Intragastric administration Oral administration |
| Metabolites |
Icariin
Icariside I Icariside II |
| Crude drug | Epimedium Herb |
| References | 1) Yihui Li, Juping Duan, Tingting Guo, Wei Xie, Shineng Yan, Bo Li, Yanqin Zhou, Yuxiang Chen, In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from Gan-kang granules and extracts of Herba Epimedii, Nepal dock root, Ficus hirta yahl. Journal of Ethnopharmacology, 124: 522–529 (2009). 2) Yan Chen, Jinyan Wang, Xiaobin Jia, Xiaobin Tan and Ming Hu, Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Molecules, 16: 1336-1348 (2011), Doi:10.3390/molecules16021336. 3) Caisheng Wu, Jinlan Zhanga, Tonghui Zhou, Baolin Guo, Yilin Wang, Jinfeng Hou, Simultaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography–tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction. Journal of Pharmaceutical and Biomedical Analysis, 54: 186–191 (2011). 4) Yu-Tse Wu, Chia-Wen Lin, Lie-Chwen Lin, Allen W. Chiu, Kuang-Kuo Chen, and Tngu-Hu Tsai, Analysis of biliary excretion of icariin in rats. J. Agric. Food Chem., 58: 9905–9911 (2010). 5) Haiyu Zhao, Miaoxuan Fan, Li Fan, Jianghao Sun, Dean Guo, Liquid chromatography–tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. Journal of Chromatography B, 878: 1113–1124 (2010). 6) Ping Shen, Shih Peng Wong, Jun Li, E.L. Yong, Simple and sensitive liquid chromatography–tandem mass spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat sera. Journal of Chromatography B, 877: 71–78 (2009). 7) Olga N. Pozharitskaya, Marina V. Karlina, Alexander N. Shikov, Vera M. Kosman, Marina N. Makarova and Valery G. Makarov, Determination of icariin in rat plasma by reverse-phase high-performance liquid chromatography after oral administration of a lipid-based suspension of Epimedium koreanum extract. Biomed. Chromatogr. 22: 625–629 (2008). 8) Yinhan Gonga, See Chung Yip, Sennappan Kanagamani Thamarai, Jie Zhang, Hian Kee Lee, E.L. Yong, Trace analysis of icariin in human serum with dansyl chloride derivatization after oral administration of Epimedium decoction by liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 860: 166–172 (2007). 9) Man Liu, Huiping Liu, Xiumei Lu, Chao Li, Zhili Xiong, Famei Li, Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC–MS/MS. Journal of Chromatography B, 860: 113–120 (2007). 10) Wen Xu, Yaping Zhang, Ming Yang, Ziyin Shen, Xinmin Zhang, Weidong Zhang, Haiyun Li, LC–MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma. Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007). 11) Gui-feng Deng, Ding-li Wang, Ming-xin Meng, Fan Hu, Tong-wei Yao, Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877: 2113–2122 (2009). |
| Remarks | ① Rats (n=6) received an intragastric administration of 50 mg/kg icariin. [Xu et al., Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007)] ② 処方Gushudan (Herba Epimedii, Fructus Cnidii, Rhizoma Drynariae and Radix Salviae Miltiorrhizae) extractの代謝[Liu et al., Journal of Chromatography B, 860: 113–120 (2007)] Pharmacokinetic parameters of icariin, icariside I and icariside II after intragastric administration of icariin to six rats at a dose of 50 mg/kg (mean ±SD). [Xu et al., Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007)] Pharmacokinetic parameters of icariin, icariside II and osthole in rats after oral administration of Gushudan (Herba Epimedii, Fructus Cnidii, Rhizoma Drynariae and Radix Salviae Miltiorrhizae) extract (n=6). Mean±SD. [Liu et al., Journal of Chromatography B, 860: 113–120 (2007)] |
