Icariside I
|
| Compound | Icariside I |
| Animal species | rat |
| Metabolism parameters |
Intragastric administration Oral administration |
| Metabolites |
Icariside I
|
| Crude drug | Epimedium Herb |
| References | 1) Haiyu Zhao, Miaoxuan Fan, Li Fan, Jianghao Sun and Dean Guo: Liquid chromatography–tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. Journal of Chromatography B, 878: 1113–1124 (2010). 2) Man Liu, Huiping Liu, Xiumei Lu, Chao Li, Zhili Xiong and Famei Li: Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC–MS/MS. Journal of Chromatography B, 860: 113–120 (2007). 3) Wen Xu, Yaping Zhang, Ming Yang, Ziyin Shen, Xinmin Zhang, Weidong Zhang and Haiyun Li: LC–MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma. Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007). |
| Remarks | ① Rats (n=6) received an intragastric administration of 50 mg/kg icariin. [Xu et al., Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007)] ② 処方Gushudan (Herba Epimedii, Fructus Cnidii, Rhizoma Drynariae and Radix Salviae Miltiorrhizae) extractの代謝[Liu et al., Journal of Chromatography B, 860: 113–120 (2007)] |
