Chlorogenic acid
|
| Compound | Chlorogenic acid |
| Animal species | rat |
| Metabolism parameters |
Intragastric administration Intragastric administration Intragastric administration |
| Metabolites |
Chlorogenic acid
|
| Crude drug | Fennel |
| References | 1) Jing Ren, Xuehua Jiang, and Chenrui Li, Investigation on the absorption kinetics of chlorogenic acid in rats by HPLC. Arch. Pharm. Res. 30: 911-916 (2007). 2) Ju Wen-zheng, Liu Fang, We Ting, Xia Xiao-yan, Tan Heng-shan, Wang Xing, Xing Ning-ning, Simultaneous determination of baicalin and chlorogenic acid in human plasma by UPLC-MS/MS. Acta Pharmaceutica Sinica 42: 1074-1077 (2007). 3) Rong Gao, Qiang Zheng, Tao Gong, Yao Fu, Li Deng, Zhi-Rong Zhang, Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. Journal of Pharmaceutical and Biomedical Analysis 43: 335–340 (2007). |
| Remarks | Chlorogenic acid (ChA), a major phenolic compound in the Flos Lonicerae, is widely used in the traditional Chinese medicine practice. The purpose of this study is to report the pharmacokinetic parameters of ChA in rats after oral administration and explore its absorption profile briefly. A two-compartment model was proposed and validated through the program to explain the apparent triphasic phenomenon of ChA in rats after intragastric administration. A rapid absorption and a relatively slow distribution followed by a slower elimination phase were observed. At the administered doses of 200, 400 and 600 mg/kg, the values of absorption half-life (tl/2 Ka) were 10.23, 18.66 and 28.13 min. The values of distribution half-life (t1/2α) were 12.35, 31.04 and 39.19 min. And the values of elimination half-life (tl/2β) were 231.64, 337.23 and 420.81 min. The volume of distribution at the three doses were 55.26, 35.56, 32.22 L/kg, respectively. The AUC0-∞ (area under the concentration-time curve) was not proportional to the administered dose. In the range of the doses examined, the absorption pharmacokinetics of ChA in rats was based on nonlinear kinetics. [Ren et al., Arch. Pharm. Res. 30: 911-916 (2007) ] Pharmacokinetic parameters of chlorogenic acid (200, 400 and 600 mg/kg, n=6) in rats after intragastric administration |
