Paeonol
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| Compound | Paeonol |
| Animal species | rat, dog, minipig and human hepatic microsome |
| Metabolism parameters | |
| Metabolites |
Paeonol
2-Hydroxy-4-methoxyacetophenone-5-O-sulfate paeonol-2-O-sulfate 2,4-Dihydroxyacetophenone 2,4-Dihydroxyacetophenone-2-O-sulfate |
| Crude drug | Moutan Bark |
| References | 1) Hui-Xin Liu, Ying Hu, Yu-Qi He, Yong Liu, Wei Li, Ling Yang, Ultra-performance liquid chromatographic–electrospray mass spectrometric determination (UPLC-ESI-MS) of O-demethylated metabolite of paeonol in vitro: Assay development, human liver microsome activities and species differences. Talanta 79: 1433–1440 (2009). 2) Yao Xiao, Ying-hao Zhang, Yu-xin Sheng and Jin-lan Zhang, LC-MS determination and pharmacokinetic studies of paeonol in rat plasma after administration of different compatibility of Su-Xiao-Xin-Tong prescriptions, Biomed. Chromatogr. 22: 527–534 (2008) 3) Ying Xie, Hua Zhou, Yuen-Fan Wong, Hong-Xi Xu, Zhi-Hong Jiang, Liang Liu,Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC–DAD-MS method. Journal of Pharmaceutical and Biomedical Analysis, 46: 748–756 (2008). |
| Remarks | A simple and sensitive method for determination of the O-demethylation activity of rat, dog, minipig, and human liver micrsomes toward paeonol using ultra-performance liquid chromatography with mass detection (UPLC-MS) has been developed. The method was successfully used to determine the kinetics of DHA activities toward paeonol in liver microsomes from different species. [Liu et al., Talanta 79: 1433–1440 (200)] |
