6-Gingerol
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| 化合物名 | 6-Gingerol |
| 動物種 | ヒト、ラット |
| 代謝パラメータ |
Oral administration Oral administration Oral administration Oral administration Oral administration Oral administration |
| 代謝物 |
[6]-Gingerol
02 03 04 05 06 [6]-Shogaol(M1) 08 |
| 関連生薬 | 乾姜 , 生姜 |
| 参考文献 | 1) Yanke Yu, Suzanna Zick, Xiaoqin Li, Peng Zou, Benjamin Wright, and Duxin Sun: Examination of the pharmacokinetics of active ingredients of ginger in humans. The American Association of Pharmaceutical Scientists Journal 2011, DOI: 10.1208/s12248-011-9286-5. 2) Marie‐Lou Gauthier, Jennifer Douat, Pascal Vachon and Francis Beaudry: Characterization of [6]‐gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry. Biomed Chromatogr. 2011 Feb 18. DOI: 10.1002/bmc.1585. 3) Suzanna M. Zick, Zora Djuric, Mack T. Ruffin, Amie J. Litzinger, Daniel P. Normolle, Meihua Rose Feng, and Dean E. Brenner: Pharmacokinetics of 6-, 8-, 10-gingerols and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 17: 1930–1936 (2008). DOI: 10.1158/1055-9965.EPI-07-2934. |
| 論文備考 | ① 被験者にPure Encapsulation's ginger を投与した後、経時的に血清中のgingerolおよびshogaol化合物濃度をHPLCで分析した。[Zick et al., Cancer Epidemiol Biomarkers Prev. 17: 1930–1936 (2008)] ②ラットを用いた代謝実験: Male Sprague–Dawley rats received a single intraperitoneal dose of 40 mg/kg and rats were kept in metabolic cages. Urine and feces samples were collected over a 24 h period for the determination of [6]‐gingerol excretion pathway by HPLC‐MS/MS. [Gauthier et al., Biomed Chromatogr. 2011 Feb 18. DIO: 10.1002/bmc.1585.] Pharmacokinetic parameters of 6-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 8-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 10-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 6-shogaol and other related compounds Mean±SD [Zick et al., Cancer Epidemiol Biomarkers Prev. 17: 1930–1936 (2008)] Estimated plasma pharmacokinetic parameters after single oral administration of 2.0 g ginger extracts [Yu et al., The American Association of Pharmaceutical Scientists Journal 2011, DOI: 10.1208/s12248-011-9286-5] : 10.1208/s12248-011-9286-5] |
