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This research was performed by utilizing the Traditional Medical & Pharmaceutical Database, Institute of Natural Medicine, University of Toyama (
Data migration from Wakanyaku Wiki Database 2020/11/26
Crude drug and kampo formula data have been migrated from Wakanyaku Wiki Database.
Addition of journal publications on exploratory research 2019/05/15
Journal publications on exploratory research have been added. For a more detailed explanation of exploratory research, please see "Link".
Release of English version of the Traditional Medical & Pharmaceutical Database 2012/12/26
Traditional Medical & Pharmaceutical Database (English version) is released on the Internet from December 26, 2012.
Journal (Exploratory Research)
2017 2019/05/15
- Nishikawa Y., Nakayama R., Obika S., Ohsaki E., Ueda K., Honda T.: Inhibition of LINE-1 retrotransposition by capsaicin. Int. J. Mol. Sci., 19(10):3243 (2018). doi: 10.3390/ijms19103243

- Terabayashi T., Hanada K., Motani K., Kosako H., Yamaoka M., Kimura T., Ishizaki T.: Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment. Genes Cells, 23(6):466-479 (2018). doi: 10.1111/gtc.12584

- Watanabe K.: Drug-repositioning approach for the discovery of anti-influenza virus activity of Japanese herbal (Kampo) medicines in vitro: Potent high activity of Daio-Kanzo-To. Evid. Based Complement. Alternat. Med., 2018:6058181 (2018). doi: 10.1155/2018/6058181
2014 2019/05/15
- Hishiki T., Kato F., Miura T., Tajima S., Toume K., Umezaki M., Takasaki T.: Hirsutine, an indole alkaloid of Uncaria rhynchophylla, inhibits late step in Dengue virus lifecycle. Front. Microbiol., 8:1674 (2017). doi: 10.3389/fmicb.2017.01674
2013 2019/05/15
- Chiba M., Ariga H., Maita H.: A splicing reporter tuned to non-AG acceptor sites reveals that luteolin enhances the recognition of non-canonical acceptor sites. Chem. Biol. Drug Des., 87(2):275-282 (2016). doi: 10.1111/cbdd.12656
2010 2019/05/15
- Wada N., Kawano Y., Fujiwara S., Kikukawa Y., Okuno Y., Tasaki M., Ueda M., Ando Y., Yoshinaga K., Ri M., Iida S., Nakashima T., Shiotsu Y., Mitsuya H., Hata H.: Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells. Int. J. Oncol., 46(3):963-972 (2015). doi: 10.3892/ijo.2014.2804

- Fujii E., Inada Y., Kakoki M., Nishimura N., Endo S., Fujiwara S., Wada N., Kawano Y., Okuno Y., Sugimoto T., Hata H.: Bufalin induces DNA damage response under hypoxic condition in myeloma cells. Oncol. Lett., 15(5):6443-6449 (2018). doi: 10.3892/ol.2018.8091

- Ishimoto T., Mano H., Ozawa T., Mori H.: Measuring CREB activation using bioluminescent probes that detect KID-KIX interaction in living cells. Bioconjug. Chem., 23(5):923-932 (2012). doi: 10.1021/bc200491j
Journal (Knowledge Cluster)
2013 2013/12/05
- Piao J.L., Cui Z.G., Furusawa Y, Ahmed K, Rehman M.U., Tabuchi Y., Kadowaki M., Kondo T.: The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells. Chem Biol Interact, 205: 119-127, 2013. [ PMID: 23811387]

- Teshigawara K., Kuboyama T., Shigyo M., Nagata A., Sugimoto K., Matsuya Y., Tohda C.: A novel compound, Denosomin ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin. Br J Pharmacol, 168: 903-919,2013. [PMID: 22978525]

- He J. Y., Zhu S., Komatsu K., Goda Y., Cai S. Q.: Genetic polymorphism of medicinally-used Codonopsis species in an internal transcribed spacer sequence of nuclear ribosomal DNA and its application to authenticate Codonopsis Radix. J. Nat. Med., 2013. 10.1007/s11418-013-0780-1 [PMID: 23765107]

- He J. Y., Zhu S., Goda Y., Cai S. Q., Komatsu K.: Quality Evaluation of Medicinally-used Codonopsis Species and Codonopsis Radix Based on the Contents of Pyrrolidine Alkaloids, Phenylpropanoids and Polyacetylenes. J. Nat. Med., 2013. 10.1007/s11418-013-0801-0 [PMID: 24203345]
2012 2013/12/05
- Wang X., Kageyama-Yahara N., Hayashi S., Yamamoto T., Kadowaki M.: Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice. Evid Based Complement Alternat Med, 2012: 862743, 2012. [PMID: 22719791]

- Ahmed K., Furusawa Y., Tabuchi Y., Emam HF., Piao JL., Hassan MA., Yamamoto T., Kondo T., Kadowaki M.: Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response. Int J Hyperther, 28: 1-8, 2012. [PMID: 22235779]

- Tohda C., Urano T., Umezaki M., Nemere I., Kuboyama T.: Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Sci Rep, 2: 535, 2012. [PMID: 22837815]

- Tohda C., Nagata A.: Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury. Evid Based Complement Alternat Med, 2012: 731208, 2012. [PMID: 22956977]

- Wang X.H., Zhu H., Konno K., Tohda C., Kazuma K., Kuboyama T., Miyanaga S.: Screening of fractions from some Chinese herbs for spinal cord injury. Chinese Journal of Experimental Traditional Medical Formulae, 18: 246-248, 2012.
2011 2013/12/05
- Kageyama-Yahara N., Wang X., Katagiri T., Wang P., Yamamoto T., Tominaga M., Kadowaki M.: Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells. Biochem Biophys Res Commun, 416: 283-288, 2011. [PMID: 22100653]

- Tohda C., Nakada R., Urano T., Okonogi A., Kuboyama T.: Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer’s disease, 5XFAD. Int J Neurosci, 121: 641-648, 2011. [PMID: 21770858]

- Oka H., Goto H., Koizumi K., Nakamura S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki I., Shimada Y.: Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evid Based Complement Alternat Med, 2011: 348686, 2011. [PMID: 21423692]

- Kimura M., Shibahara N., Hikiami H., Yoshida T., Jo M., Kaneko M., Nogami T., Fujimoto M., Goto H., Shimada Y.: Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats. Evid Based Complement Alternat Med., 2011: 592791, 2011. [PMID: 21660308]

- Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.: Cinnamaldehide and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia. J Trad Med, 28: 149-157, 2011.

- Bai Y. J., Tohda C., Zhu S., Hattori M., Komatsu K.: Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. J. Nat. Med., 65: 417-423, 2011. [PMID: 21301979]

- Kitani Y., Zhu S., Batkhuu J., Sanchir C., Komatsu K.: Genetic diversity of Ephedra plants in Mongolia inferred from nrDNA ITS sequence. Biol. Pharm. Bull., 34: 717-726, 2011. [PMID: 21532163]

- Zhu S., Oya M., Bai Y. J., Tanaka K., Komatsu K., Maruyama T., Goda Y., Kawasaki T., Fujita M., Shibata T.: Genetic and chemical diversity of Eleutherococcus senticosus and molecular identification of Siberian ginseng by PCR-RFLP analysis based on chloroplast trnK intron sequence. Food Chemistry, 129: 1844-1850, 2011. [Abstract]



Information on genetic analysis

Metabolism information on chemical compounds included in crude drugs

Traditional Medical & Pharmaceutical Database

Section of Pharmacognosy,
Division of Medicinal Resources,
Department of Research and Development,
Institute of Natural Medicine,
University of Toyama
2630 Sugitani, Toyama 930-0194 Japan
TEL: +81-76-434-7601
FAX: +81-76-434-5064