Burcine N
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| 化合物名 | Burcine N |
| 動物種 | ヒト腸内細菌株 Lactobacillus acidophilus |
| 代謝パラメータ | |
| 代謝物 |
Brucine N-oxide
16-Hydroxybrucine Brucine |
| 関連生薬 | 馬銭子 |
| 参考文献 | 1) El-Mekkawy S., Meselhy M. R., Kawata Y., Kadota S., Hattori M., and Namba T.: Metabolism of strychnine N-oxide and brucine N-Oxide by human intestinal bacteria. Planta Med., 59, 347-350 (1993). |
| 論文備考 | ※Screening of bacterial strains for their ability to metabolize brucine N-oxide (1) Brucine N-oxide (10 mg; 1) in DMSO (0.1ml) was incubated with each bacterial suspension (10 ml) under anaerobic conditions for 4 d and the metabolites were quantitatively analyzed by HPLC using CH3CN-0.03 M Na2HPO4 (45 : 55) as a mobile phase. [El-Mekkawy et al., Planta Med., 59, 347-350 (1993)] ※Incubation of brucine N-oxide (1) with Lactobacillus acidophilus Brucine N-oxide (1,500 mg) was anaerobically incubated for 4d. The residue after the evaporation of solvent was applied to preparative TLC (solvent system B) to isolate metabolites (2 and 3). [El-Mekkawy et al., Planta Med., 59, 347-350 (1993)] |
