Daidzein
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| Compound | Daidzein |
| Animal species | human intestinal microflora |
| Metabolism parameters | |
| Metabolites |
Daidzein
Dihydrodaidzein Equol |
| Crude drug | Pueraria Root |
| References | 1) Jin J. S., Nishihata T., Kakiuchi N. and Hattori M.: Biotransformation of C-glucosyl- isoflavone puerarinto estrogenic (3S)-equol in co-culture of two human intestinal bacteria. Biol. Pharm. Bull., 31, 1621-1625 (2008). 2) Jin J. S., Kitahara M., Sakamoto M., Hattori M., and Benno Y.: Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol. Int. J. System. Evol. Microbio., 60, 1721–1724 (2010). |
| Remarks | ・Isolation of a human intestinal bacterial strain capable of converting daidzein to equol A bacterial suspension was repeatedly cultured in 2 ml of GAM broth containing 0.1 mM daidzein as a substrate at 37˚C in an anaerobic incubator. A portion of the culture, possessing metabolic activity, was seeded on GAM agar plates and anaerobically incubated for 72 h at 37˚C. Colonies were repeatedly screened for their activity of transforming daidzein to obtain a single daidzein-metabolizing bacterium. [Jin et al., Biol. Pharm. Bull., 31, 1621-1625 (2008)] |
