Icariside II
|
| Compound | Icariside II |
| Animal species | rat |
| Metabolism parameters |
Intragastric administration Oral administration |
| Metabolites |
Icariside II
|
| Crude drug | Epimedium Herb |
| References | 1) Haiyu Zhao, Miaoxuan Fan, Li Fan, Jianghao Sun, Dean Guo, Liquid chromatography–tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. Journal of Chromatography B, 878: 1113–1124 (2010). 2) Man Liu, Huiping Liu, Xiumei Lu, Chao Li, Zhili Xiong, Famei Li, Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC–MS/MS. Journal of Chromatography B, 860: 113–120, (2007). 3) Wen Xu, Yaping Zhang, Ming Yang, Ziyin Shen, Xinmin Zhang, Weidong Zhang, Haiyun Li, LC–MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma. Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007). |
| Remarks | ① Rats (n=6) received an intragastric administration of 50 mg/kg icariin. [Xu et al., Journal of Pharmaceutical and Biomedical Analysis 45: 667–672 (2007)] ② 処方Gushudan (Herba Epimedii, Fructus Cnidii, Rhizoma Drynariae and Radix Salviae Miltiorrhizae) extractの代謝[Liu et al., Journal of Chromatography B, 860: 113–120 (2007)] |
