Naringenin
|
| Compound | Naringenin |
| Animal species | rat |
| Metabolism parameters |
Intravenous administration Intravenous administration |
| Metabolites |
(2R)-Naringenin
(2S)-Naringenin |
| Crude drug | Immature Orange |
| References | 1) Jaime A. Yàñez, Connie M. Remsberg, Nicole D. Miranda, Karina R. Vega-Villa, Preston K. Andrews and Neal M. Davies, Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices. Biopharm. Drug Dispos. 29: 63–82 (2008). |
| Remarks | The majority of pharmacokinetic studies of individual flavonoids or after ingestion of foodstuffs have overlooked the chirality of some of these xenobiotics. In order to characterize for the first time the stereoselective pharmacokinetics of three flavonoids, hesperetin, naringenin and eriodictyol were intravenously administered (20 mg/kg) to male Sprague-Dawley rats, and their stereospecific content was assessed in various fruit juices. Concentrations in serum, urine and fruit juices were characterized via HPLC and verified by LC/MS. [Yàñez et al., Biopharm. Drug Dispos., 29: 63–82 (2008)] Stereospecific pharmacokinetics of eriodictyol in serum after i.v. administration in rats (20 mg/kg) (mean±SEM, n=6) Stereospecific pharmacokinetics of hesperetin, and naringenin in serum after i.v. administration in rats (20 mg/kg) (mean±SEM, n=6) |
