Oral administration
| Dose | 125 mg/kg mixed solution (containing 25 mg costunolide and 100 mg dehydrocostuslacton) |
| K | |
| T1/2 | 4.967 h |
| Tmax | 9.000 h |
| V | |
| CL | Cl/F 75.54 L/h/kg |
| Cmax | 0.024 L/h/kg |
| AUC | 0.322 mg/Lh 0.331 mg/Lh |
| Range of AUC | 0–48 0–∞ |
| MRT | |
| MAT | |
| Others | Vd/F 0.191 L/kg t1/2ka 4.394 R2 0.927 |
| Comment | t1/2, terminal elimination half-life; Cmax, the peak plasma concentration; tmax, peak time; Vd, apparent volume of distribution; Cl, total body clearance; AUC0–, area under the plasma concentration vs time profiles from 0 to infinity. [Hu et al., Biomed. |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
