Intravenous administration
| Dose | 20 mg/kg |
| K | kel 0.100 ± 0.003 (h ± 1) serum ke 0.028 ± 0.001 (h ± 1) urine |
| T1/2 | 6.989 ± 0.258 (h) serum 25.202 ± 1.072 (h) urine |
| Tmax | |
| V | Vss 4.180 ± 0.222 l/kg |
| CL | CLrenal 0.015 ± 0.002 l/h/kg CLhepatic 0.401 ± ± 0.023 l/h/kg CLtot0.416 ± 0.023 l/h/kg |
| Cmax | |
| AUC | 24.434 ± 1.476 mg ± h/ml 0.747 ± 0.012 % |
| Range of AUC | inf 72-inf extrapolated |
| MRT | 12.244 ± 0.335 h |
| MAT | |
| Others | fe 3.771 ± 0.548 % Extraction ratio (ER) 0.230 ± 0.013 |
| Comment | aDenotes statistical significant difference (p<0.05) between enantiomers. [Yàñez et al., Biopharm. Drug Dispos., 29: 63–82 (2008)] |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
