Intravenous administration
| Dose | 20 mg/kg |
| K | kel 0.189 ± 0.024a (h ± 1) serum ke 0.027 ± 0.001 (h ± 1)urine |
| T1/2 | 3.727 ± 0.470a (h) serum 25.943 ± 0.652 (h) urine |
| Tmax | |
| V | Vss 7.342 ± 0.491a l/kg |
| CL | CLrenal 0.042 ± 0.016 l/h/kg CLhepatic1.310 ± 0.091a l/h/kg CLtot 1.352 ± 0.107a l/h/kg |
| Cmax | |
| AUC | 7.443 ± 0.588a mg ± h/ml 2.680 ± 0.029a % |
| Range of AUC | inf 72-inf extrapolated |
| MRT | 5.527 ± 1.005a h |
| MAT | |
| Others | fe 3.047 ± 0.916 % Extraction ratio (ER) 0.753 ± 0.052a |
| Comment | |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
