Intravenous administration
| Dose | 20 mg/kg |
| K | kel 0.193 ± 0.011 (h ± 1) serum ke 0.038 ± 0.007 (h ± 1)urine |
| T1/2 | 3.648 ± 0.213 (h) serum 12.769 ± 2.508 (h) urine |
| Tmax | |
| V | Vss 3.918 ± 0.150 l/kg |
| CL | CLrenal 0.058 ± 0.012 l/h/kg CLhepatic 0.693 ± 0.023a l/h/kg CLtot 0.751 ± 0.029a l/h/kg |
| Cmax | |
| AUC | 13.410 ± 0.465a mg ± h/ml 2.748 ± 0.093a % |
| Range of AUC | inf 72-inf extrapolated |
| MRT | 6.327 ± 0.627 h |
| MAT | |
| Others | fe7.542 ± 1.489 % Extraction ratio (ER) 0.398 ± 0.013a |
| Comment | |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
