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Cimicifuga Rhizome
Cimicifuga Rhizome
Market name:升麻
Photo location:Museum of Materia Medica, Inst. of Nat. Med.
TMPW No.:1049
Cimicifuga dahurica
Plant name:Cimicifuga dahurica
Photo location:Liaoning Prov., China
Photo date:1992

Latin name Cimicifugae Rhizoma
Botanical source: Family name Ranunculaceae
Botanical source: Plant name - Cimicifuga dahurica Huth (IPNI:709429-1)
- Cimicifuga heracleifolia Komarov (IPNI:709435-1)
- Cimicifuga foetida Linné (IPNI:709433-1)
- Cimicifuga simplex Wormskjold ex De Candolle (IPNI:709448-1)
Part used Rhizome
Empirical criteria for quality selection Good one is large without fine roots and the outer surface is black. The cross section is white or light green. (NI)
Constituents Triterpenoids:
Cimigenol 3-arabinoside, Cimigol, Isodahurinol, Acerionol, Cimicifugoside, 26-O-Methylcimifugoside, Cimifugenin A, 26-O-Methylcimifugenin A, Cimicifugenol, Acetylshengmanol xyloside, Friedelin;
[C. dahurica]: Cimigenol, Cimigenol xyloside, Dahurinol;
[C. acerina]: Cimigenol, Acerinol, 25-O-Acetylcimigenol, 25-O-Methylcimigenol, Dehydroxy-15-O-methylcimigenol, 15-O-Methylcimigenol, 25-O-Acetylcimigenoside, 25-O-Methylcimigenoside;
[C. foetida]: Cimicidanol, Foetidinol, Acetylacteol-3-O-arabinoside, 25-Anhydrocimigenol-3-O-β-xyloside, Cimicidanol-3-O-β-xyloside, Cimicidol-3-O-β-xyloside, Cimicifol, Cimicinol, Foetidinol-3-O-β-xyloside, 15-α-Hydroxycimicidol-3-O-β-xyloside, 15-α-Hydroxyfoetidinol-3-O-β-xyloside
[C. heracleifolia]: 24-epi-Acerinol, 25-O-Acetyl-7,8-didehydrocimigenol, 7,8-Didehydrocimigenol, 24-epi-7,8-Didehydrocimigenol, Heracleifolinol 3-keto-24-epi-7,8-didehydrocimigenol, 3'-O-Acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-xyloside, 2',4'-Di-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-xyloside, 7,8-Didehydro-24-O-acetylhydroshengmanol-3-O-β-xyloside, 24-epi-7,8-Didehydrocimigenol-3-O-β-xyloside

[C. dahurica]: β-Sitosterol;
[C. acerina]: β-Sitosterol

[C. dahurica]: Ferulic acid, Isoferulic acid

[C. dahurica]: Visnagin;
[C. simplex]: Khellol, Ammiol, Cimifugin
Pharmacological effects Antifebrile, analgesic, antiinflammatory, sedative, antihypertensive, inhibitior of bone resorption.
Indications As an antifebrile, antidote, and anti inflammatory drug, it is used to treat fever, headache, pharyngitis, cold, measles, and anal prolapse.
Diseases Urticaria, Anal fistula, Pruritus, Hematochezia due to proctoptosis, Descent of the uterus, Measles, Erosion of the root of tooth, Bad breath, Stomatitis, Swelling and pain of the throat, Headache, Chronic diarrhea
Formulas otsujito , otsujitokyodaio , kamigedokuto , shikonboreito , shomakakkonto , shin'iseihaito , jingyokyokatsuto , jingyobofuto , seinetsuhokito , hochuekkito , rikkosan , reitakutsukito , reitakutsukitokashin'i
Meridian tropism Lung, Spleen, Large intestine, Stomach
Property Slightly cold
Flavor Sweet, Acrid/pungent
Classification in "Shen-non Ben-cao Jing" Superior
TCM: Classification Diaphoretics
TCM: Medicinal effects To relieve exterior syndrome, clear away toxic material and let out skin eruption, lift up yang-energy.
Used for common cold of wind-heat type, dental pain, aphthae, pharyngitis, laryngitis, measles with indistinct eruption, anal prolapse, uterine prolapse.
Remarks Listed in the Japanese Pharmacopoeia 18th ed.
References NI: N. Isshiki, Methods of Quality Evaluation and Preparation of Wakan-yaku [Wakanyaku no ryohi kanbetsu-ho oyobi chosei-ho], Tohodo Shoten, Tokyo, 1987.
DNA sequences of medicinal plants
Gene Region
Nuclear Chloroplast Mitochondria
Botanical source: Plant name 5Ss 18S ITS1 5.8S ITS2 26S others trnH-psbA matK trnK trnK-rps16 trnT-L trnL trnL-F rbcL rpoC1 ndhF others
Cimicifuga dahurica Huth (IPNI:709429-1)
Cimicifuga foetida Linné (IPNI:709433-1)
Cimicifuga heracleifolia Komarov (IPNI:709435-1)
Cimicifuga simplex Wormskjold ex De Candolle (IPNI:709448-1)


Information on genetic analysis

Metabolism information on chemical compounds included in crude drugs

Traditional Medical & Pharmaceutical Database

Section of Pharmacognosy,
Division of Medicinal Resources,
Department of Research and Development,
Institute of Natural Medicine,
University of Toyama
2630 Sugitani, Toyama 930-0194 Japan
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