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Euodia Fruit
Euodia Fruit
Market name:呉茱萸
Photo location:Museum of Materia Medica, Inst. of Nat. Med.
TMPW No.:1778
Euodia rutaecarpa
Plant name:Euodia rutaecarpa
Photo location:Kyoto Pref., Japan
Photo date:1993
Photographer:H. Fujino

Latin name Euodiae Fructus
Botanical source: Family name Rutaceae
Botanical source: Plant name - Euodia officinalis Dode (IPNI:773085-1)
- Euodia bodinieri Dode (IPNI:772935-1)
- Euodia rutaecarpa Hooker filius et Thomson (IPNI:773127-1)
Part used Ripe fruit
Empirical criteria for quality selection Good one is black in color and has strong pungency and bitterness. (TN)
Constituents Other aliphatic and related compounds:
Goshuyic acid


Limonin (=Evodin), Rutaevin, Evodol

Flavanones & Dihydroflavonols:
E. rutaecarpa: Evodioside B (leaf)

Evodiamine, Rutaecarpine, Hydroxyevodiamine (=Rhetsinine), Evocarpine, N,N-Dimethyl-5-methoxytryptamine, NMethylanthranylamide, Synephrine, Higenamine

Purine derivatives:
Cyclic GMP

E. rutaecarpa: 6α-Acetoxy-5-epilimonin, 6β-Acetoxy-5-epilimonin
Pharmacological effects Increase in the blood pressure, accelerated respiration, increase in the blood flow (fraction of alcohol extraction), analgesia, rising temperature (evodiamine, rutaecarpine), inducing labor pains, hemostasis, central excitation (β-indolethyl-amine), hallucination (N,N-dimethyl-5-methoxytryptamine), adrenergic action, cardiotonic action (synephrine, hygenamine).
Indications As a stomachic with warm nature, painkiller, diuretic, for relieving vomiting, it is applied to treat headache due to rising of noxious fluid, nausea, a feeling of stuffiness in the chest, abdominal pain due to cold of deficiency type, poor circulation and chilblains. It is used as insecticide and bath agent.
Diseases Headache, Nausea, Vomitting, Upper abdominal pain, Coldness of limbs, Lower abdominal pain, Menorrhalgia, Extension of menstrual cycle, Full stomach, Diarrhea, Cold-natured, Chilblain, Stomatitis
Formulas unkeito , en'nenhangeto , kyutsugan , keimeisankabukuryo , goshuyuto , teikiin , tokishigyakukagoshuyushokyoto , henseishinkiin , hontonto (chugoho)
Meridian tropism Liver, Stomach, Spleen, Kidney
Property Extremely hot
Flavor Acrid/pungent, Bitter
Classification in "Shen-non Ben-cao Jing" Middle
TCM: Classification Drugs for dispelling internal cold
TCM: Medicinal effects To dissipate cold and relieve pain, downbear counterflow to check vomiting, assist yang to check diarrhea.
Used for reverting yin headache, abdominal pain caused by cold abdominal colic, cold-dampness tinea pedis, menstruation with abdominal pain, distending pain in the epigastrium and abdomen, vomiting, acid regurgitation, diarrhea before dawn.
Remarks Listed in the Japanese Pharmacopoeia 18th ed.
References TN: T. Namba & Y. Tsuda ed., Outline of Pharmacognosy, a Textbook, 3rd ed., Nankodo Co., Ltd., Tokyo, 1998.
DNA sequences of medicinal plants
Gene Region
Nuclear Chloroplast Mitochondria
Botanical source: Plant name 5Ss 18S ITS1 5.8S ITS2 26S others trnH-psbA matK trnK trnK-rps16 trnT-L trnL trnL-F rbcL rpoC1 ndhF others
Euodia bodinieri Dode (IPNI:772935-1)


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Traditional Medical & Pharmaceutical Database

Section of Pharmacognosy,
Division of Medicinal Resources,
Department of Research and Development,
Institute of Natural Medicine,
University of Toyama
2630 Sugitani, Toyama 930-0194 Japan
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