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Uncaria Hook
Uncaria Hook
Market name:釣藤鈎
Photo location:Museum of Materia Medica, Inst. of Nat. Med.
TMPW No.:16221
Uncaria rhynchophylla
Plant name:Uncaria rhynchophylla
Photo location:Nara Pref., Japan
Photo date:1997
Photographer:K. Komatsu

Latin name Uncariae Uncis cum Ramulus
Botanical source: Family name Rubiaceae
Botanical source: Plant name - Uncaria rhynchophylla Miquel (IPNI:768297-1)
- Uncaria sinensis Haviland (IPNI:768314-1)
- Uncaria macrophylla Wallich (IPNI:768275-1)
Part used Hook-bearing stem or branch
Empirical criteria for quality selection The best one consists of hooks only. Generally, the vine of good one is thin and has many soft hooks with a tinge of purple. (TN)
Constituents Indole alkaloids:
U. rhynchophylla: Rhynchophylline, Corynoxeine, Isorhynchophylline, Isocorynoxeine, Hirsutine, 18,19-Dehydrohirsutine (=Hirsutein), Dihydrocorynantheine, Corynantheine;
U. sinensis: Geissoschizine methylether, Hirsuteine, Hirsutine, Rhynchophylline, Corynoxeine, Isorhynchophylline, Isocorynoxeine;
U. kawakamii: Uncarine A, Uncarine B, Mitraphylline
Pharmacological effects Respiration (low dose: excitation; high dose: inhibition), antispasm, antivirus, vasodilation, α-adrenergic blocker, antiarrhythmia, calcium antagonism, inhibition of central serotonin receptor, sedation. Increase in sleep (geissoschizine methylether), decrease in blood pressure (hirsutine, isorhynchophylline).
Indications As an antispasmodic and painkiller, it is applied to treat headache and dizziness due to fever or hypertension, sclerosis of cerebral arteries, convulsion, spasm of child, epilepsy, coma with high fever, malaria and rheumatism.
Diseases High fever, Convulsion, Headache, Vertigo, Stagger, Hypertension, Cerebral arteriosclerosis, Red eye, Convulsion, Tantrum
Formulas shichimotsukokato , chotosan , tokishakuyakusankaogichoto , yokukankashakuyaku , yokukansan , yokukansankashakuyakuoren , yokukansankachimpihange
Meridian tropism Liver, Pericardium
Property Slightly cold
Flavor Sweet
Classification in "Shen-non Ben-cao Jing"  
TCM: Classification Anticonvulsants
TCM: Medicinal effects To remove heat, subdue hyperactivity of the liver, and arrest convulsions.: For headache, dizziness, convulsion, spasm of muscle, eclampsia, and hypertension.
Remarks Listed in the Japanese Pharmacopoeia 18th ed.
References TN: T. Namba & Y. Tsuda ed., Outline of Pharmacognosy, a Textbook, 3rd ed., Nankodo Co., Ltd., Tokyo, 1998.
DNA sequences of medicinal plants
Gene Region
Nuclear Chloroplast Mitochondria
Botanical source: Plant name 5Ss 18S ITS1 5.8S ITS2 26S others trnH-psbA matK trnK trnK-rps16 trnT-L trnL trnL-F rbcL rpoC1 ndhF others
Uncaria sinensis Haviland (IPNI:768314-1)
Uncaria macrophylla Wallich (IPNI:768275-1)
Uncaria rhynchophylla Miquel (IPNI:768297-1)


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Section of Pharmacognosy,
Division of Medicinal Resources,
Department of Research and Development,
Institute of Natural Medicine,
University of Toyama
2630 Sugitani, Toyama 930-0194 Japan
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