25-Hydroxyprotopanaxadiol
|
| Compound | 25-Hydroxyprotopanaxadiol |
| Animal species | nude mice, rat |
| Metabolism parameters | |
| Metabolites |
25-Hydroxyprotopanaxadiol
|
| Crude drug | Ginseng |
| References | 1) Miao Hao, Wei Wang, Yuqing Zhao, Ruiwen Zhang, Hui Wang, Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors. Eur J Drug Metab Pharmacokinet 35:109–113 (2011). 2) Xiangrong Zhang, Dan Zhang, Jinghua Xu, Jingkai Gu, Yuqing Zhao, Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography–mass spectrometry and its application in rat pharmacokinetic studies. Journal of Chromatography B, 858: 65–70 (2007). 3) Dan Zhang, Yingwu Wang, Jiangbin Han, Weisong Yu, Lili Deng, J. Paul Fawcett, Zeyuan Liu, Jingkai Gu, Rapid and sensitive LC–MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma. Journal of Chromatography B, 877: 581–585 (2009). 4) Xiangrong Zhang, Dan Zhang, Jinghua Xu, Jingkai Gu, Yuqing Zhao, Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography–mass spectrometry and its application in rat pharmacokinetic studies. Journal of Chromatography B, 858: 65–70 (2007). |
| Remarks | After intravenous and oral administration to nude mice bearing xenografts of human pancreatic tumors at doses of 10 and 20 mg/kg body weight, respectively, 25-OH-PPD was rapidly absorbed and distributed in plasma and in all tissues examined, including the tumors, with all Cmax > 2 μg/ml or μg/g and tmax < 1 h. The absolute oral bioavailability of 25-OH-PPD was relatively high, compared with other ginsenosides. [Hao et al., Eur J Drug Metab Pharmacokinet 35:109–113 (2011)] |
