Osthol (Osthole)
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| Compound | Osthol (Osthole) |
| Animal species | rat |
| Metabolism parameters |
Oral administration |
| Metabolites |
Osthol
Osthenol 7-Methoxy-8-(3-methyl-1,3-butadienyl)-2H-1-benzopyran-2-one |
| Crude drug | Aralia Rhizome |
| References | 1) Man Liu, Huiping Liu, Xiumei Lu, Chao Li, Zhili Xiong, Famei Li, Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC–MS/MS. Journal of Chromatography B, 860: 113–120 (2007). 2) Zhan Lifang, Hu Xiao, Wang Ping, Zhang Lei, Metabolism of osthol in isolated hepatocytes of rat. Acta Pharmaceutica Sinica, 44: 1131-1135 (2009). 3) Zhenting Yuan, Haiyan Xu, KeWang, Zhonghua Zhao, Ming Hu Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 49: 1226–1232 (2009). |
| Remarks | ラットを用いてGushudan (Herba Epimedii, Fructus Cnidii, Rhizoma Drynariae and Radix Salviae Miltiorrhizae) extractの体内動態を調べる。 Pharmakokinetic parameters of icariin, icariside II and osthole in rats after oral administration of Gushudan (Herba Epimedii, Fructus Cnidii, Rhizoma Drynariae and Radix Salviae Miltiorrhizae) extract (n=6). Mean±SD. [Liu et al., Journal of Chromatography B, 860: 113–120 (2007)] |
