Oral administration
| Dose | 37.5 mg/kg |
| K | |
| T1/2 | |
| Tmax | 180.0 ± 0.82 min |
| V | |
| CL | |
| Cmax | 351.5 ± 1.2 ng/ml |
| AUC | 191.3 ± 4.2 μgml^-1min |
| Range of AUC | 0-∞ |
| MRT | |
| MAT | |
| Others | |
| Comment | a p< 0.05, b p< 0.01 compared with conventional rats; Data are expressed as means±S.D. (n = 4). Ber, berberine; M1, berberrubine; M2, thalifendine: M3, demethyleneberberine; M4, jatrorrhizine. |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
