Intravenous administration
| Dose | 20 mg/kg |
| K | kel 0.174 ± 0.017 (h ± 1) serum ke 0.016 ± 0.002 (h ± 1) urine |
| T1/2 | 4.163 ± 0.361 (h) serum 46.688 ± 7.000 (h) urine |
| Tmax | |
| V | Vss 4.854 ± 0.247 l/kg |
| CL | CLrenal 0.041 ± 0.007 l/h/kg CLhepatic 0.791 ± 0.063 l/h/kg CLtot 0.832 ± 0.063 l/h/kg |
| Cmax | |
| AUC | 12.367 ± 0.933 mg ± h/ml 2.706 ± 0.047 % |
| Range of AUC | inf 72-inf extrapolated |
| MRT | 7.272 ± 0.557 h |
| MAT | |
| Others | fe 5.070 ± 0.989 % Extraction ratio (ER) 0.454 ± 0.036 |
| Comment | aDenotes statistical significant difference (p<0.05) between enantiomers. [Yàñez et al., Biopharm. Drug Dispos., 29: 63–82 (2008)] |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
