Intravenous administration
| Dose | 10 mg/kg (n=6) |
| K | |
| T1/2 | 16.6 ± 3.6 |
| Tmax | |
| V | Vss 542 ± 85.1 mL/kg |
| CL | 56.7 ± 8.5* mL/min/kg CLR 2.8 ± 1.0 mL/min/kg CLNR 54.6 ± 9.9* mL/min/kg |
| Cmax | |
| AUC | 179.4 ± 24.5* μg・min/mL |
| Range of AUC | 0-∞ |
| MRT | 9.1 ± 1.1 min |
| MAT | |
| Others | Ae0-24h 6.2 ± 3.1 % of dose GI24h 0.48 ± 0.37 % of dose |
| Comment | * The values were significantly different from 2 and 5 mg/kg p<0.05). |
| Remarks |
Others:Others unclassified into each parameter
Comment:Comment on metabolism parameters
Comment:Comment on metabolism parameters
