Ganoderic Acid A
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| Compound | Ganoderic Acid A |
| Animal species | animal |
| Metabolism parameters |
Intravenous administration Intravenous administration Oral administration Oral administration |
| Metabolites |
Ganoderic acid A
|
| Crude drug | Ganoderma |
| References | 1) Gao J. J., Min B. S., Akao T., Meselhy M. R., and Hattori M.: Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum. J. Trad. Med., 18, 154-160 (2001). |
| Remarks | Male Wistar rats (6 weeks old, SLC Co., Hamamatsu) were used. Animals were fed standard laboratory chow with water ad libitum, maintained for one week, and were fasted overnight before the experiments. For intravenous administration, GAA dissolved in 5% DMSO-saline was injected into a tail vein of four rats at doses of 5 and 25 mg/kg, respectively. Blood samples were taken from another tail vein using a heparinized capillary micro-tube at 5, 15, 30 min, 1, 2, 4, 6, and 8 hr after the injection, and immediately separated by centrifugation. The serum sample obtained was kept at -20°C until use for measuring the concentration of GAA by enzyme immuno assay. For oral administration, GAA dissolved in 5% DMSO-H2O was given to rats (n= 4 at each point) at doses of 5 and 50 mg/kg, respectively. Blood samples were obtained from a tail vein at 10, 20, 40 min, 1, 2, 4 and 8 hr. |
