Bergenin
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| Compound | Bergenin |
| Animal species | human intestinal microflora |
| Metabolism parameters | |
| Metabolites |
Bergenin
4-O-Methylgallic acid |
| Crude drug | Mallotus Bark |
| References | 1) Hattori M., Shu Y. Z., Tomimori T., Kobashi K. and Namba T.: A bacterial cleavage of the C-glucosyl bond of mangiferin and bergenin. Phytochemistry, 28, 1289-1290 (1989). |
| Remarks | Fresh feces obtained from a healthy man was thoroughly suspended in 30 volumes or the anaerobic dilution medium by bubbling with oxygen-free CO2 and filtered through gauze to eliminate the residue. Bergenin (100 mg) was anaerobically incubated with an intestinal bacterial mixture (200 ml). The EtOAc extract was chromatographed on a silica gel column (24 x 24 cm) with CHCl3-MeOH (100:1) to yield a metabolite 4-O-methylgallic acid (73 mg). |
