Precatorin II
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| Compound | Precatorin II |
| Animal species | human intestinal microflora |
| Metabolism parameters | |
| Metabolites |
Precatorin II
Precatorin I 1-(2,6-dihydroxy-3,4-dimethoxy-5-((2S,3R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)-3-(4-hydroxyphenyl)propan-1-one 1-(2', 6'-Dihydroxyl-3', 4'-dimethoxyphenyl)-3-(4''-hydroxyphenyl) propan-1-one 4,5-Dimethoxybenzene-1,3-diol 3-(4'-Hydroxyphenyl)propionic Acid 3-Phenylpropionic Acid |
| Crude drug | |
| References | 1) Li Y., Meselhy M. R., Wang L., Ma C., Nakamura N., and Hattori M.: Biotransformation of a C-glycosylflavone, abrusin 2"-O-β-D-apioside, by human intestinal bacteria. Chem. Pharm. Bull., 48, 1239-1241 (2000). 2) Ma C. M., Nakamura N., and Hattori M.: Saponins and C-glucosyl flavones from the seeds of Abrus precatorius. Chem. Pharm. Bull. 46, 982-987 (1998). |
| Remarks | ※Preparation of an intestinal bacterial mixture Fresh feces obtained from a healthy subject were thoroughly suspended in 100-fold of 50 mM K-phosphate buffer (pH 7.3) to give a human fecal suspension, which was use in this experiment. [Li et al., Chem. Pharm. Bull., 48, 1239-1241 (2000)] ※Time course of the transformation of precatorin II Precatorin II (3, 10 mmol in 200 ml of DMSO) was added to a human fecal suspension (5%, 3.8 ml) and incubated at 37°C in an anaerobic incubator. Samples were picked up at intervals and treated as mentioned above. Metabolites were quantitatively determined by HPLC. [Li et al., Chem. Pharm. Bull., 48, 1239-1241 (2000)] |
