Piperine
|
| Compound | Piperine |
| Animal species | rat |
| Metabolism parameters | |
| Metabolites |
Piperine
|
| Crude drug | |
| References | 1) Xinan Wu, Xingguo Chen and Zhide Hu: High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma. Talanta 59: 115-121 (2003). 2) Böhmdorfer M, Maier-Salamon A, Taferner B, Reznicek G, Thalhammer T, Hering S, Hüfner A, Schühly W and Jäger W: In vitro metabolism and disposition of honokiol in rat and human livers. Journal of Pharmaceutical Sciences, 100: 3506–3516 (2011). 3) Qin Yu, Jin Xiang, WenFu Tang, MaoZhi Liang, YongPing Qin and Feng Nan: Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 877: 2025–2031 (2009). |
| Remarks | Separate sets of animals (150 - 160 g) were orally administered the three spice principles at dosages of 30 mg (capsaicin), 170 mg (piperine) and 500 mg (curcumin) / kg body weight. The tissue concentrations of administered spice compounds were determined by HPLC. A maximum of 10.8 per cent of administered piperine was seen in tissues at 6 h. Absorption of the administered piperine was about 96 per cent. Piperine was not detectable in urine. [Suresh et al., Indian J Med Res 131, 682-691 (2010)] |
