Glabridin

Compound Glabridin 
Animal species human 
Metabolism parameters Oral administration
Oral administration
Oral administration
Metabolites Glabridin
Crude drug Glycyrrhiza 
References 1) Fumiki Aoki, Kaku Nakagawa, Mitsuaki Kitano, Hideyuki Ikematsu, Kenjirou Nakamura, Shinichi Yokota, Yuji Tominaga, Naoki Arai, and Tatsumasa Mae, Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. Journal of the American College of Nutrition, 26, 209–218 (2007). 
Remarks Licorice flavonoid oil (LFO: Kaneka Glavonoid Rich Oil™) is a new dietary ingredient containing licorice flavonoids dissolved in medium-chain triglycerides (MCT). A single-dose and two multiple-dose studies at low (300 mg), moderate (600 mg) and high (1200mg) daily doses of LFO were carried out using a placebo-controlled single-blind design. Pharmacokinetic analysis in the single-dose study with healthy male subjects (n= 5) showed that glabridin was absorbed and reached the maximum concentration (Cmax) after approximately 4 h (Tmax), and then eliminated relatively slowly in a single phase with a T1/2 of approximately 10 h at all doses. The Cmax and AUC0–24 h increased almost linearly with dose. The multiple-dose studies with healthy male and female subjects for 1 week and 4 weeks suggested that plasma glabridin reached steady state levels within 2 weeks with a single daily administration of 300 to 1200 mg/day LFO. [Aoki et al., Journal of the American College of Nutrition, 26, 209–218 (2007)]

Pharmacokinetic parameters of glabridin in healthy male subjects after a single oral administration of licorice flavonoid oil (LFO)a,b
 
 

TOPICS

Information on genetic analysis

Metabolism information on chemical compounds included in crude drugs

Traditional Medical & Pharmaceutical Database


Section of Pharmacognosy,
Division of Medicinal Resources,
Department of Research and Development,
Institute of Natural Medicine,
University of Toyama
2630 Sugitani, Toyama 930-0194 Japan
TEL: +81-76-434-7601
FAX: +81-76-434-5064