Resibufogenin
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| Compound | Resibufogenin |
| Animal species | rat intestinal microflora, Nocardia sp. NRRL 5646 |
| Metabolism parameters |
Intragastric administration |
| Metabolites |
Resibufogenin
3-Acetyl resibufogenin 3-Acetyl-15β-hydroxybufotalin |
| Crude drug | Toad Venom |
| References | 1) Jian Zhang, Yang Sun, Ji-Hua Liu, Bo-Yang Yu, and Qiang Xu, A Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure–activityrelationship (SAR). Bioorganic & Medicinal Chemistry Letters 17, 6062–6065 (2007). 2) Wen Xu, Heng Luo, Yaping Zhang, Lei Shan, Haiyun Li, Ming Yang, Runhui Liu, Weidong Zhang, Simultaneous determination of five main active bufadienolides of Chan Su in rat plasma by liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 859, 157–163 (2007). |
| Remarks | ① Chan Suに含まれるbufadienolide [Zhang et al., Bioorg. Med. Chem. Lett. 17, 6062–6065 (2007)]. ② Chan Su胃内投与後の血清中のbufadienolide [Xu et al., J.Chromato. B, 859, 157–163 (2007)]. 【代謝パラメータ】 Pharmakokinetic parameters of bufadienolides in serum after intragastric administration of Chan Su extract to rats at a dose of 100 mg /kg (n=6) Mean±SD |
