Costunolide
|
| Compound | Costunolide |
| Animal species | rat |
| Metabolism parameters |
Oral administration |
| Metabolites |
Costunolide
|
| Crude drug | Saussurea Root |
| References | 1) Fangdi Hu, Shilan Feng, Yuqiong Wu, Yingyan Bi, Chunming Wang and Wen Li, Quantitative analysis of costunolide and dehydrocostuslactone in rat plasma by ultraperformance liquid chromatography–electrospray ionization–mass spectrometry. Biomed. Chromatogr. 25: 547–554 (2011). |
| Remarks | After a single oral dose of the mix of costunolide and dehydrocostuslactone from Saussurea lappa or Laurus novocanariensis was administered to six rats, their plasma concentrations were analyzed by UPLC-MS/MS. [Hu et al., Biomed. Chromatogr. 25: 547–554 (2011)] Single dose pharmacokinetic parameters for costunolide and dehydrocostuslactone after application of their mix to rats (n = 6). AUC0–48 (mg/L h) was calculated for concentration vs time profiles from 0 min to 48 h by the trapezoidal method. |
