6-Shogaol
|
| Compound | 6-Shogaol |
| Animal species | human |
| Metabolism parameters |
Oral administration Oral administration Oral administration |
| Metabolites |
10-Gingerol
|
| Crude drug | Ginger , Processed Ginger |
| References | 1) Yanke Yu, Suzanna Zick, Xiaoqin Li, Peng Zou, Benjamin Wright, and Duxin Sun, Examination of the pharmacokinetics of active ingredients of ginger in humans. 31550-7416/11/0000-0001/0 # 2011 American Association of Pharmaceutical Scientists, DOI: 10.1208/s12248-011-9286-5 2) Marie‐Lou Gauthier, Jennifer Douat, Pascal Vachon and Francis Beaudry Characterization of [6]‐gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry. Biomed Chromatogr. 2011 Feb 18. doi: 10.1002/bmc.1585. [Epub ahead of print] 3) Suzanna M. Zick, Zora Djuric, Mack T. Ruffin, Amie J. Litzinger, Daniel P. Normolle, Meihua Rose Feng, and Dean E. Brenner, Pharmacokinetics of 6-, 8-, 10-gingerols and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 2008 August; 17(8): 1930–1936. doi: 10.1158/1055-9965.EPI-07-2934. |
| Remarks | 被験者にPure Encapsulation's ginger を投与した後、経時的に血清中のgingerolおよびshogaol化合物濃度をHPLCで分析した。[Zick et al., Cancer Epidemiol Biomarkers Prev. 17: 1930–1936 (2008)] Pharmacokinetic parameters of 10-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 6-shogaol and other related compounds Mean±SD Pharmacokinetic parameters of 6-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 8-gingerol and other related compounds Mean±SD [Zick et al., Cancer Epidemiol Biomarkers Prev. 17: 1930–1936 (2008)] |
