6-Shogaol
|
| Compound | 6-Shogaol |
| Animal species | human, rat |
| Metabolism parameters |
Oral administration Oral administration Oral administration |
| Metabolites |
8-Gingerol
|
| Crude drug | Ginger , Processed Ginger |
| References | 1) Yanke Yu, Suzanna Zick, Xiaoqin Li, Peng Zou, Benjamin Wright, and Duxin Sun: Examination of the pharmacokinetics of active ingredients of ginger in humans. The American Association of Pharmaceutical Scientists Journal 2011, DOI: 10.1208/s12248-011-9286-5. 2) Marie‐Lou Gauthier, Jennifer Douata, Pascal Vachona and Francis Beaudry: Characterization of [6]‐gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry. Biomed Chromatogr. 2011, DOI: 10.1002/bmc.1585. 3) Suzanna M. Zick, Zora Djuric, Mack T. Ruffin, Amie J. Litzinger, Daniel P. Normolle, Meihua Rose Feng, and Dean E. Brenner: Pharmacokinetics of 6-, 8-, 10-gingerols and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 17: 1930-1936 (2008). DOI: 10.1158/1055-9965. EPI-07-2934. |
| Remarks | ※被験者にPure Encapsulation's ginger を投与した後、経時的に血清中のgingerolおよびshogaol濃度をHPLCで分析した。[Zick et al., Cancer Epidemiol Biomarkers Prev. 17: 1930-1936 (2008)] Pharmacokinetic parameters of 8-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 10-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 6-gingerol and other related compounds Mean±SD Pharmacokinetic parameters of 6-shogaol and other related compounds Mean±SD [Zick et al., Cancer Epidemiol Biomarkers Prev. 17: 1930-1936 (2008)] |
